منابع مشابه
MCP-1-dependent signaling in CCR2(-/-) aortic smooth muscle cells.
Monocyte chemoattractant protein-1 (MCP-1, CCL2) is a mediator of inflammation that has been implicated in the pathogenesis of a wide variety of human diseases. CCR2, a heterotrimeric G-coupled receptor, is the only known receptor that functions at physiologic concentrations of MCP-1. Despite the importance of CCR2 in mediating MCP-1 responses, several recent studies have suggested that there m...
متن کاملMCP-1/CCR2 system in diabetic nephropathy EFFECT OF THE MCP-1/CCR2 SYSTEM ON NEPHRIN EXPRESSION IN STREPTOZOTOCIN-TREATED MICE AND HUMAN CULTURED PODOCYTES
This is an uncopyedited electronic version of an article accepted for publication in Diabetes. The American Diabetes Association, publisher of Diabetes, is not responsible for any errors or omissions in this version of the manuscript or any version derived from it by third parties. The definitive publisher-authenticated version will be available in a future issue of Diabetes in print and online...
متن کاملAspergillus antigen induces robust Th2 cytokine production, inflammation, airway hyperreactivity and fibrosis in the absence of MCP-1 or CCR2
BACKGROUND Asthma is characterized by type 2 T-helper cell (Th2) inflammation, goblet cell hyperplasia, airway hyperreactivity, and airway fibrosis. Monocyte chemoattractant protein-1 (MCP-1 or CCL2) and its receptor, CCR2, have been shown to play important roles in the development of Th2 inflammation. CCR2-deficient mice have been found to have altered inflammatory and physiologic responses in...
متن کاملAssociation of MCP-1 and CCR2 polymorphisms with the risk of late acute rejection after renal transplantation in Korean patients
Among the factors modulating transplant rejection, chemokines and their respective receptors deserve special attention. Increased expression of monocyte chemoattractant protein-1 (MCP-1) and its corresponding receptor (chemokine receptor-2, CCR2) has been implicated in renal transplant rejection. To determine the impact of the MCP-1-2518G and CCR2-64I genotypes on renal allograft function, 167 ...
متن کاملmcp-1, ccr2 and ccr5 polymorphisms in tunisian patients with atopic asthma.
chemokines and their receptors play an important role in the late inflammatory stage of asthma. in this study, we aimed to investigate polymorphisms of mcp-1 (ccl2), ccr2 and ccr5 which can affect qualitatively and/or quantitatively their production and thus influence both susceptibility and severity of asthma and its clinical and biological features. mcp-1 (a/g -2518), ccr2 (+/64i), ...
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ژورنال
عنوان ژورنال: Ensho Saisei
سال: 2004
ISSN: 1346-8022,1880-5795
DOI: 10.2492/jsir.24.567